Brand  (β version)

PDB ID: 1LG6

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Ligands
Code Name Style Show Link
SCN Thiocyanate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1LG6   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal Structure Analysis of HCA II Mutant T199P in Complex with Thiocyanate
Release Data : 2002-07-24
Compound :
mol_id molecule chains synonym
1 Carbonic anhydrase II A Carbonate dehydratase II, CA-II
ec: 4.2.1.1
mutation: T199P
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Huang, S., Sjoblom, B., Sauer-Eriksson, A.E., Jonsson, B.-H.
Keywords : HCAII mutant T199P-SCN complex, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Organization of an efficient carbonic anhydrase: implications for the mechanism based on structure-function studies of a T199P/C206S mutant.

Huang, S.,Sjoblom, B.,Sauer-Eriksson, A.E.  et al.
(2002)  Biochemistry  41 : 7628 - 7635

PubMed: 12056894
DOI: 10.1021/bi020053o

Reaction

Chain : A
UniProt : P00918 (CAH2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + hydrogencarbonate = CO2 + H2O 4.2.1.1 PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308
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urea = cyanamide + H2O 4.2.1.69 PubMed:10550681, PubMed:11015219
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