Het-PDB Navi2 (PDB: 1LCA)

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Ligands
Code	Name		Style	Show	Link
CB3	10-propargyl-5,8-dideazafolic acid				PoSSuM
UMP	2'-deoxyuridine 5'-monophosphate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1LCA

Code :

1LCA PDBj RCSB PDB PDBe

Header :

TRANSFERASE (METHYLTRANSFERASE)

Title :

LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717

Release Data :

1995-10-15

Compound :

mol_id	molecule	chains	synonym
1	THYMIDYLATE SYNTHASE	A	TS, LCTS
	ec: 2.1.1.45

Source :

mol_id	organism_scientific
1	Lactobacillus casei (taxid:1582)

Authors :

Birdsall, D.L., Finer-Moore, J., Stroud, R.M.

Keywords :

NUCLEOTIDE SYNTHASE, TRANSFERASE (METHYLTRANSFERASE)

Exp. method :

X-RAY DIFFRACTION ( 2.5 Å )

Citation :

Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.

Finer-Moore, J.,Fauman, E.B.,Foster, P.G. et al.
(1993) J.Mol.Biol. 232 : 1101 - 1116

Chain :

UniProt :

P00469 (TYSY_LACCA)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP	2.1.1.45	HAMAP-Rule:MF_00008
	-	HAMAP-Rule:MF_00008

PDB ID: 1LCA