Brand  (β version)

PDB ID: 1LBZ

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
FBP 1,6-di-O-phosphono-beta-D-fructofuranose PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1LBZ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of a complex (P32 crystal form) of dual activity FBPase/IMPase (AF2372) from Archaeoglobus fulgidus with 3 Calcium ions and Fructose-1,6 bisphosphate
Release Data : 2002-05-22
Compound :
mol_id molecule chains synonym
1 fructose 1,6-bisphosphatase/inositol monophosphatase A,B FBPase/IMPase
ec: 3.1.3.11, 3.1.3.25
Source :
mol_id organism_scientific expression_system
1 Archaeoglobus fulgidus  (taxid:2234) Escherichia coli  (taxid:562)
gene: AF2372
Authors : Stieglitz, K.A., Johnson, K.A., Yang, H., Roberts, M.F., Seaton, B.A., Head, J.F., Stec, B.
Keywords : dual activity, FBPase, IMPase, archaeal phosphatase, substrate complex, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop.

Stieglitz, K.A.,Johnson, K.A.,Yang, H.  et al.
(2002)  J.Biol.Chem.  277 : 22863 - 22874

PubMed: 11940584
DOI: 10.1074/jbc.M201042200

Crystal structure and catalytic mechanism of the MJ0109 gene product: a bifunctional enzyme with inositol monophosphatase and fructose 1,6-bisphosphatase activities.

Johnson, K.A.,Chen, L.,Yang, H.  et al.
(2001)  Biochemistry  40 : 618 - 630

DOI: 10.1021/bi0016422

Reaction

Chain : A, B
UniProt : O30298 (BSUHB_ARCFU)
Reaction: EC: Evidence:
Physiological Direction:
beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate 3.1.3.11 PubMed:11062561, PubMed:11940584
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a myo-inositol phosphate + H2O = myo-inositol + phosphate 3.1.3.25 PubMed:10747806, PubMed:11062561, PubMed:11940584
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