Het-PDB Navi2 (PDB: 1LBC)

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Ligands
Code	Name	Link
ZN	Zinc ion	PoSSuM
GLU	Glutamic acid	PoSSuM
CYZ	Cyclothiazide	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1LBC

Code :

1LBC PDBj RCSB PDB PDBe

Header :

MEMBRANE PROTEIN

Title :

Crystal structure of GluR2 ligand binding core (S1S2J-N775S) in complex with cyclothiazide (CTZ) as well as glutamate at 1.8 A resolution

Release Data :

2002-05-29

Compound :

mol_id	molecule	chains	synonym
1	Glutamine Receptor 2	A,B,C	GLUR-2, GLUR-B, GLUR-K2, GLUTAMATE RECEPTOR IONOTROPIC AMPA 2
	fragment: ligand binding core mutation: N775S

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Norway rat	Escherichia coli BL21(DE3) (taxid:469008)
	gene: GluR-2 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pETGQ

Authors :

Sun, Y., Olson, R., Horning, M., Armstrong, N., Mayer, M., Gouaux, E.

Keywords :

AMPA receptor, GluR2, S1S2, ligand binding core, point mutation, N775S, cyclothiazide, CTZ, agonist, Membrane protein

Exp. method :

X-RAY DIFFRACTION ( 1.8 Å )

Citation :

Mechanism of glutamate receptor desensitization.

Sun, Y.,Olson, R.,Horning, M. et al.
(2002) Nature 417 : 245 - 253

PDB ID: 1LBC