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Ligands
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KAI 3-(carboxymethyl)-4-isopropenylproline
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Code : 1LBB   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Crystal structure of the GluR2 ligand binding domain mutant (S1S2J-N754D) in complex with kainate at 2.1 A resolution
Release Data : 2002-06-05
Compound :
mol_id molecule chains synonym
1 Glutamine receptor 2 A GLUR-2, GLUR-B, GLUR-K2, GLUTAMATE RECEPTOR IONOTROPIC AMPA 2
fragment: ligand binding core (flop)
mutation: N754D
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli BL21(DE3)  (taxid:469008)
gene: GluR-2
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pETGQ
Authors : Sun, Y., Olson, R., Horning, M., Armstrong, N., Mayer, M., Gouaux, E.
Keywords : AMPA receptor, GluR2, S1S2, Ligand-binding core, Point mutation, N754D, Agonist, Kainate, MEMBRANE PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Mechanism of glutamate receptor desensitization.

Sun, Y.,Olson, R.,Horning, M.  et al.
(2002)  Nature  417 : 245 - 253

PubMed: 12015593
DOI: 10.1038/417245a

Chain : A
UniProt : P19491 (GRIA2_RAT)
Reaction : -