Brand  (β version)

PDB ID: 1L0V

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Ligands
Code Name Style Show Link
OAA Oxaloacetate ion PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
F3S Fe3-s4 cluster PoSSuM
SF4 Iron/sulfur cluster PoSSuM
MQ7 Menaquinone-7 PoSSuM
CE1 O-dodecanyl octaethylene glycol PoSSuM
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Structure summary

Code : 1L0V   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Quinol-Fumarate Reductase with Menaquinol Molecules
Release Data : 2002-03-13
Compound :
mol_id molecule chains
1 Fumarate reductase flavoprotein subunit A,M
ec: 1.3.99.1
mol_id molecule chains
2 Fumarate reductase iron-sulfur protein B,N
ec: 1.3.99.1
mol_id molecule chains
3 Fumarate reductase 15 kDa hydrophobic protein C,O
mol_id molecule chains
4 Fumarate reductase 13 kDa hydrophobic protein D,P
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: FrdA
expression_system_strain: DW35
expression_system_vector_type: plasmid
expression_system_plasmid: pH3
mol_id organism_scientific expression_system
2 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: FrdB
expression_system_strain: DW35
expression_system_vector_type: plasmid
expression_system_plasmid: pH3
mol_id organism_scientific expression_system
3 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: FrdC
expression_system_strain: DW35
expression_system_vector_type: plasmid
expression_system_plasmid: pH3
mol_id organism_scientific expression_system
4 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: FrdD
expression_system_strain: DW35
expression_system_vector_type: plasmid
expression_system_plasmid: pH3
Authors : Iverson, T.M., Luna-Chavez, C., Croal, L.R., Cecchini, G., Rees, D.C.
Keywords : fumarate reductase, succinate dehydrogenase, complex II, quinol, membrane protein, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 3.3 Å )
Citation :

Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site.

Iverson, T.M.,Luna-Chavez, C.,Croal, L.R.  et al.
(2002)  J.Biol.Chem.  277 : 16124 - 16130

PubMed: 11850430
DOI: 10.1074/jbc.M200815200

Structure of the E. coli Fumarate Reductase Respiratory Complex

Iverson, T.M.,Luna-Chavez, C.,Cecchini, G.  et al.
(1999)  Science  284 : 1961 - 1966

DOI: 10.1126/science.284.5422.1961

Overexpression, Purification, and Crystallization of the Membrane-Bound Fumarate Reductase from Eschericia coli

Luna-Chavez, C.,Iverson, T.M.,Rees, D.C.  et al.
(2000)  Protein Expr.Purif.  19 : 188 - 196

DOI: 10.1006/prep.2000.1238

Reaction

Chain : A, M
UniProt : P00363 (FRDA_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = a quinol + fumarate 1.3.5.1 PubMed:11850430
-
a menaquinone + succinate = a menaquinol + fumarate 1.3.5.1 PubMed:10373108
-
Chain : B, N
UniProt : P0AC47 (FRDB_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = a quinol + fumarate 1.3.5.1 PubMed:11850430
-
a menaquinone + succinate = a menaquinol + fumarate 1.3.5.1 PubMed:10373108
-
Chain : C, O
UniProt : P0A8Q0 (FRDC_ECOLI)
Reaction : -
Chain : D, P
UniProt : P0A8Q3 (FRDD_ECOLI)
Reaction : -