Het-PDB Navi2 (PDB: 1L0C)

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Ligands
Code	Name		Style	Show	Link
COT	Coa-S-acetyl tryptamine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1L0C

Code :

1L0C PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Investigation of the Roles of Catalytic Residues in Serotonin N-Acetyltransferase

Release Data :

2002-06-19

Compound :

mol_id	molecule	chains	synonym
1	Serotonin N-acetyltransferase	A	ARALKYLAMINE N-ACETYLTRANSFERASE, AA-NAT, SEROTONIN ACETYLASE
	ec: 2.3.1.87 mutation: Y168F

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Ovis aries (taxid:9940)	Sheep	Escherichia coli (taxid:562)
	gene: AANAT expression_system_strain: BL21(DE3)PLYSS expression_system_vector_type: Plasmid expression_system_plasmid: PGEX-6P-1

Authors :

Scheibner, K.A., De Angelis, J., Burley, S.K., Cole, P.A.

Keywords :

Enzyme-inhibitor complex, bisubstrate analog, alternate conformations, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.3 Å )

Citation :

Investigation of the roles of catalytic residues in serotonin N-acetyltransferase.

Scheibner, K.A.,De Angelis, J.,Burley, S.K. et al.
(2002) J.Biol.Chem. 277 : 18118 - 18126

Chain :

UniProt :

Q29495 (SNAT_SHEEP)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+)	2.3.1.87	PubMed:10319816, PubMed:11884405, PubMed:11902838, PubMed:18362150
	-

PDB ID: 1L0C