Brand  (β version)

PDB ID: 1KZJ

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Ligands
Code Name Style Show Link
UMP 2'-deoxyuridine 5'-monophosphate PoSSuM
CB3 10-propargyl-5,8-dideazafolic acid PoSSuM
Non-standard Residues
Code Name Show
CXM N-carboxymethionine
Glycosylation
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Modification
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Structure summary

Code : 1KZJ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of EcTS W80G/dUMP/CB3717 Complex
Release Data : 2002-07-03
Compound :
mol_id molecule chains synonym
1 Thymidylate synthase A,B,C,D,E,F TS, TSase
ec: 2.1.1.45
mutation: W80G
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
Authors : Fritz, T.A., Liu, L., Finer-Moore, J.S., Stroud, R.M.
Keywords : Enzyme substrate cofactor analog complex, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.

Fritz, T.A.,Liu, L.,Finer-Moore, J.S.  et al.
(2002)  Biochemistry  41 : 7021 - 7029

PubMed: 12033935
DOI: 10.1021/bi012108c

Reaction

Chain : A, B, C, D, E, F
UniProt : P0A884 (TYSY_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP 2.1.1.45 HAMAP-Rule:MF_00008, PubMed:2223754, PubMed:3286637, PubMed:9826509
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