Brand  (β version)

PDB ID: 1KZ8

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Ligands
Code Name Style Show Link
AMP Adenosine monophosphate PoSSuM
MN Manganese (II) ion PoSSuM
PFE {4-[3-(6,7-diethoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol PoSSuM
F6P 6-O-phosphono-beta-D-fructofuranose PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1KZ8   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : CRYSTAL STRUCTURE OF PORCINE FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH A NOVEL ALLOSTERIC-SITE INHIBITOR
Release Data : 2002-10-16
Compound :
mol_id molecule chains synonym
1 FRUCTOSE-1,6-BISPHOSPHATASE A,F D-fructose-1,6-bisphosphate 1-phosphohydrolase, FBPase
ec: 3.1.3.11
Source :
mol_id organism_scientific organism_common expression_system
1 Sus scrofa  (taxid:9823) Pig Escherichia coli  (taxid:562)
Authors : Wright, S.W., Carlo, A.A., Carty, M.D., Danley, D.E., Hageman, D.L., Karam, G.A., Levy, C.B., Mansour, M.N., Mathiowetz, A.M., McClure, L.D., Nestor, N.B., McPherson, R.K., Pandit, J., Pustilnik, L.R., Schulte, G.K., Soeller, W.C., Treadway, J.L., Wang, I.-K., Bauer, P.H.
Keywords : HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

ANILINOQUINAZOLINE INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE BIND AT A NOVEL ALLOSTERIC SITE: SYNTHESIS, IN VITRO CHARACTERIZATION, AND X-RAY CRYSTALLOGRAPHY

Wright, S.W.,Carlo, A.A.,Carty, M.D.  et al.
(2002)  J.MED.CHEM.  45 : 3865 - 3877

PubMed: 12190310
DOI: 10.1021/jm010496a

Reaction

Chain : A, F
UniProt : P00636 (F16P1_PIG)
Reaction: EC: Evidence:
Physiological Direction:
beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate 3.1.3.11 PubMed:15767255, PubMed:1313579
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