Brand  (β version)

PDB ID: 1KVM

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Ligands
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PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1KVM   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : X-ray Crystal Structure of AmpC WT beta-Lactamase in Complex with Covalently Bound Cephalothin
Release Data : 2002-03-13
Compound :
mol_id molecule chains synonym
1 beta-lactamase A,B Cephalosporinase
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: K12
expression_system_strain: JM109
expression_system_vector_type: plasmid
expression_system_plasmid: pOGO295
Authors : Beadle, B.M., Trehan, I., Focia, P.J., Shoichet, B.K.
Keywords : amide hydrolase, beta-lactamase, cephalothin, acyl-enzyme complex, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.06 Å )
Citation :

Structural milestones in the reaction pathway of an amide hydrolase: substrate, acyl, and product complexes of cephalothin with AmpC beta-lactamase.

Beadle, B.M.,Trehan, I.,Focia, P.J.  et al.
(2002)  Structure  10 : 413 - 424

PubMed: 12005439
DOI: 10.1016/S0969-2126(02)00725-6

Reaction

Chain : A, B
UniProt : P00811 (AMPC_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE-ProRule:PRU10102, PubMed:12323371, PubMed:3264154, PubMed:3264155, PubMed:6998377
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