Het-PDB Navi2 (PDB: 1KTT)

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Ligands
Code	Name		Style	Show	Link
C02	4-(5-benzenesulfonylamino-1-methyl-1h-benzoimidazol-2-ylmethyl)-benzamidine				PoSSuM

Non-standard Residues
Code	Name	Show
TYS	O-sulfo-L-tyrosine

Glycosylation
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Download interaction data: 1KTT

Code :

1KTT PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Thrombin inhibitor complex

Release Data :

2002-02-06

Compound :

mol_id	molecule	chains	synonym
1	thrombin	A	coagulation factor II, alpha thrombin
	ec: 3.4.21.5 fragment: light chain

mol_id	molecule	chains	synonym
2	thrombin	B	coagulation factor II, alpha thrombin
	ec: 3.4.21.5 fragment: heavy chain

mol_id	molecule	chains
3	hirudin IIB	C

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific	organism_common
3	Hirudo medicinalis (taxid:6421)	Medicinal leech

Authors :

Nar, H.

Keywords :

blood coagulation, inhibition, blood clotting, HYDROLASE-HYDROLASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

Structure-based design of novel potent nonpeptide thrombin inhibitors.

Hauel, N.H.,Nar, H.,Priepke, H. et al.
(2002) J.Med.Chem. 45 : 1757 - 1766

PubMed: 11960487
DOI: 10.1021/jm0109513

Chain :

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

Chain :	C
UniProt :	P28506 (HIR2B_HIRME)
Reaction :	-

PDB ID: 1KTT

Hetero Atom Contents

Structure summary

Reaction