Het-PDB Navi2 (PDB: 1KSN)

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Ligands
Code	Name		Style	Show	Link
CA	Calcium ion				PoSSuM
FXV	Methyl-3-(4'-N-oxopyridylphenoyl)-3-methyl-2-(M-amidinobenzyl)-propionate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1KSN

Code :

1KSN PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal Structure of Human Coagulation Factor XA Complexed with FXV673

Release Data :

2002-06-19

Compound :

mol_id	molecule	chains
1	COAGULATION FACTOR XA	A
	ec: 3.4.21.6 fragment: ACTIVATED FACTOR XA, HEAVY CHAIN

mol_id	molecule	chains
2	COAGULATION FACTOR XA	B
	ec: 3.4.21.6 fragment: FACTOR X LIGHT CHAIN

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human

Authors :

Maignan, S., Guilloteau, J.P.

Keywords :

HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.1 Å )

Citation :

Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity.

Guertin, K.R.,Gardner, C.J.,Klein, S.I. et al.
(2002) Bioorg.Med.Chem.Lett. 12 : 1671 - 1674

PubMed: 12039587
DOI: 10.1016/S0960-894X(02)00213-5

Chain :

UniProt :

P00742 (FA10_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Thr and then Arg-\|-Ile bonds in prothrombin to form thrombin.	3.4.21.6	-
	-	-

PDB ID: 1KSN

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Structure summary

Reaction