Brand  (β version)

PDB ID: 1KRC

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Ligands
Code Name Style Show Link
CO2 Carbon dioxide PoSSuM
NI Nickel (II) ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1KRC   PDBj   RCSB PDB   PDBe
Header : HYDROLASE (UREA AMIDO)
Title : CRYSTAL STRUCTURE OF KLEBSIELLA AEROGENES UREASE, ITS APOENZYME AND TWO ACTIVE SITE MUTANTS
Release Data : 1995-10-15
Compound :
mol_id molecule chains
1 UREASE A
ec: 3.5.1.5
mutation: H(C 320)A
mol_id molecule chains
2 UREASE B
ec: 3.5.1.5
mutation: H(C 320)A
mol_id molecule chains
3 UREASE C
ec: 3.5.1.5
mutation: H(C 320)A
Source :
mol_id organism_scientific
1 Klebsiella aerogenes  (taxid:28451)
organ: BEAN
mol_id organism_scientific
2 Klebsiella aerogenes  (taxid:28451)
organ: BEAN
mol_id organism_scientific
3 Klebsiella aerogenes  (taxid:28451)
organ: BEAN
Authors : Jabri, E., Karplus, P.A.
Keywords : ACTIVE SITE MUTANT, NICKEL METALLOENZYME, HYDROLASE (UREA AMIDO)
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Structures of the Klebsiella aerogenes urease apoenzyme and two active-site mutants.

Jabri, E.,Karplus, P.A.
(1996)  Biochemistry  35 : 10616 - 10626

PubMed: 8718850
DOI: 10.1021/bi960424z

The Crystal Structure of Urease from Klebsiella Aerogenes

Jabri, E.,Carr, M.B.,Hausinger, R.P.  et al.
(1995)  Science  268 : 998

Site-Directed Mutagenesis of Klebsiella Aerogenes Urease: Identification of Histidine Residues that Appear to Function in Nickel Ligation, Substrate Binding, and Catalysis

Park, I.-L.,Hausinger, R.P.
(1993)  Protein Sci.  2 : 1034

Preliminary Crystallographic Studies of Urease from Jack Bean and from Klebsiella Aerogenes

Jabri, E.,Lee, M.H.,Hausinger, R.P.  et al.
(1992)  J.Mol.Biol.  227 : 934

Reaction

Chain : A
UniProt : P18316 (URE3_KLEAE)
Reaction: EC: Evidence:
Physiological Direction:
2 H(+) + H2O + urea = CO2 + 2 NH4(+) 3.5.1.5 HAMAP-Rule:MF_00739, PubMed:10500143, PubMed:11015224, PubMed:1400317, PubMed:2211515, PubMed:7721685, PubMed:7855593, PubMed:7909161, PubMed:8318888, PubMed:8808930
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Chain : B
UniProt : P18315 (URE2_KLEAE)
Reaction: EC: Evidence:
Physiological Direction:
2 H(+) + H2O + urea = CO2 + 2 NH4(+) 3.5.1.5 HAMAP-Rule:MF_01954, PubMed:10500143, PubMed:11015224, PubMed:1400317, PubMed:2211515, PubMed:7721685, PubMed:7855593, PubMed:7909161, PubMed:8318888, PubMed:8808930
-
Chain : C
UniProt : P18314 (URE1_KLEAE)
Reaction: EC: Evidence:
Physiological Direction:
2 H(+) + H2O + urea = CO2 + 2 NH4(+) 3.5.1.5 HAMAP-Rule:MF_01953, PubMed:10500143, PubMed:11015224, PubMed:1400317, PubMed:2211515, PubMed:7721685, PubMed:7855593, PubMed:7909161, PubMed:8318888, PubMed:8808930
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