Brand  (β version)

PDB ID: 1KP3

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Ligands
Code Name Style Show Link
ATP Adenosine-5'-triphosphate PoSSuM
CIR Citrulline PoSSuM
GAI Guanidine PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1KP3   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Crystal Structure of E. coli Argininosuccinate Synthetase in Complex with ATP and Citrulline
Release Data : 2002-04-17
Compound :
mol_id molecule chains
1 argininosuccinate synthetase A
ec: 6.3.4.5
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: ARGG
expression_system_strain: BB101
expression_system_vector_type: PLASMID
expression_system_plasmid: pET21b
Authors : Lemke, C.T., Howell, P.L.
Keywords : N-Type ATP pyrophosphatase, LIGASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Substrate Induced Conformational Changes in Argininosuccinate Synthetase

Lemke, C.T.,Howell, P.L.
(2002)  J.Biol.Chem.  277 : 13074 - 13081

PubMed: 11809762
DOI: 10.1074/jbc.M112436200

The 1.6 A Crystal Structure of E. coli Argininosuccinate Synthetase Suggests a Conformational Change during Catalysis

Lemke, C.T.,Howell, P.L.
(2001)  Structure  9 : 1153 - 1164

DOI: 10.1016/S0969-2126(01)00683-9

Reaction

Chain : A
UniProt : P0A6E4 (ASSY_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-aspartate + L-citrulline = 2-(N(omega)-L- arginino)succinate + AMP + diphosphate + H(+) 6.3.4.5 -
-