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Ligands
Code Name Style Show Link
FON N-{[4-({[(6r)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid
GLY Glycine
PLP Pyridoxal-5'-phosphate
Non-standard Residues
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Glycosylation
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Code : 1KL2   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of Serine Hydroxymethyltransferase Complexed with Glycine and 5-formyl tetrahydrofolate
Release Data : 2002-07-10
Compound :
mol_id molecule chains synonym
1 Serine Hydroxymethyltransferase A,B SERINE METHYLASE, SHMT
ec: 2.1.2.1
Source :
mol_id organism_scientific expression_system
1 Geobacillus stearothermophilus  (taxid:1422) Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pRSETC
Authors : Trivedi, V., Gupta, A., Jala, V.R., Saravanan, P., Rao, G.S.J., Rao, N.A., Savithri, H.S., Subramanya, H.S.
Keywords : SHMT PLP tetrahydrofolate, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism.

Trivedi, V.,Gupta, A.,Jala, V.R.  et al.
(2002)  J.Biol.Chem.  277 : 17161 - 17169

PubMed: 11877399
DOI: 10.1074/jbc.M111976200

Chain : A, B
UniProt : Q7SIB6 (Q7SIB6_GEOSE)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine 2.1.2.1 HAMAP-Rule:MF_00051
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