Het-PDB Navi2 (PDB: 1KL1)

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Ligands
Code	Name		Style	Show	Link
GLY	Glycine				PoSSuM
PLP	Pyridoxal-5'-phosphate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1KL1

Code :

1KL1 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal Structure of Serine Hydroxymethyltransferase Complexed with Glycine

Release Data :

2002-07-10

Compound :

mol_id	molecule	chains	synonym
1	Serine Hydroxymethyltransferase	A	SERINE METHYLASE, SHMT
	ec: 2.1.2.1

Source :

mol_id	organism_scientific	expression_system
1	Geobacillus stearothermophilus (taxid:1422)	Escherichia coli BL21(DE3) (taxid:469008)
	expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pRSETC

Authors :

Trivedi, V., Gupta, A., Jala, V.R., Saravanan, P., Rao, G.S.J., Rao, N.A., Savithri, H.S., Subramanya, H.S.

Keywords :

SHMT PLP tetrahydrofolate, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 1.93 Å )

Citation :

Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism.

Trivedi, V.,Gupta, A.,Jala, V.R. et al.
(2002) J.Biol.Chem. 277 : 17161 - 17169

PubMed: 11877399
DOI: 10.1074/jbc.M111976200

Chain :

UniProt :

Q7SIB6 (Q7SIB6_GEOSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine	2.1.2.1	HAMAP-Rule:MF_00051
	-	HAMAP-Rule:MF_00051

PDB ID: 1KL1

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