Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

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Ligands
Code Name Link
LU Lutetium (III) ion
Code : 1KHV
Header : TRANSFERASE
Title : Crystal Structure of Rabbit Hemorrhagic Disease Virus RNA-dependent RNA polymerase complexed with Lu3+
Release Data : 2002-01-16
Compound :
mol_id molecule chains synonym
1 RNA-DIRECTED RNA POLYMERASE A,B RNA-dependent RNA polymerase
ec: 2.7.7.48
fragment: (RESIDUES 1252-1767)
Source :
mol_id organism_scientific expression_system
1 Rabbit hemorrhagic disease virus  (taxid:11976) Escherichia coli  (taxid:562)
expression_system_strain: XL1-Blue
expression_system_vector_type: plasmid
expression_system_plasmid: pGEX-3D
Authors : Ng, K.K., Cherney, M.M., Vazquez, A.L., Machin, A., Alonso, J.M., Parra, F., James, M.N.
Keywords : RNA-dependent RNA polymerase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase.

Ng, K.K.,Cherney, M.M.,Vazquez, A.L.  et al.
(2002)  J.Biol.Chem.  277 : 1381 - 1387

PubMed: 11677245
DOI: 10.1074/jbc.M109261200

Chain : A, B
UniProt : P27410 (POLG_RHDVF)
Reaction : NTP + H(2)O = NDP + phosphate.
Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu-|-Xaa and the P1' position is occupied by Gly-|-Yaa.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).