Brand  (β version)

PDB ID: 1KFY

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Ligands
Code Name Style Show Link
OAA Oxaloacetate ion PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
F3S Fe3-s4 cluster PoSSuM
SF4 Iron/sulfur cluster PoSSuM
BRS 2-[1-(4-chloro-phenyl)-ethyl]-4,6-dinitro-phenol PoSSuM
CE1 O-dodecanyl octaethylene glycol PoSSuM
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Structure summary

Code : 1KFY   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : QUINOL-FUMARATE REDUCTASE WITH QUINOL INHIBITOR 2-[1-(4-CHLORO-PHENYL)-ETHYL]-4,6-DINITRO-PHENOL
Release Data : 2002-03-13
Compound :
mol_id molecule chains
1 FUMARATE REDUCTASE FLAVOPROTEIN A,M
ec: 1.3.99.1
mol_id molecule chains
2 Fumarate reductase iron-sulfur protein B,N
ec: 1.3.99.1
mol_id molecule chains
3 FUMARATE REDUCTASE 15 KDA HYDROPHOBIC PROTEIN C,O
mol_id molecule chains
4 FUMARATE REDUCTASE 13 KDA HYDROPHOBIC PROTEIN D,P
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_vector_type: PLASMID
expression_system_plasmid: PFA
mol_id organism_scientific expression_system
2 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_vector_type: PLASMID
expression_system_plasmid: PFA
mol_id organism_scientific expression_system
3 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_vector_type: PLASMID
expression_system_plasmid: PFA
mol_id organism_scientific expression_system
4 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_vector_type: PLASMID
expression_system_plasmid: PFA
Authors : Iverson, T.M., Luna-Chavez, C., Croal, L.R., Cecchini, G., Rees, D.C.
Keywords : fumarate reductase, succinate dehydrogenase, quinone, quinol, respiration, membrane protein, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 3.6 Å )
Citation :

Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site.

Iverson, T.M.,Luna-Chavez, C.,Croal, L.R.  et al.
(2002)  J.Biol.Chem.  277 : 16124 - 16130

PubMed: 11850430
DOI: 10.1074/jbc.M200815200

Structure of the Escherichia coli Fumarate Reductase Respiratory Complex

Iverson, T.M.,Luna-Chavez, C.,Cecchini, G.  et al.
(1999)  Science  284 : 1961 - 1966

DOI: 10.1126/science.284.5422.1961

Reaction

Chain : A, M
UniProt : P00363 (FRDA_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = fumarate + a quinol 1.3.5.1 PubMed:11850430
-
a menaquinone + succinate = a menaquinol + fumarate 1.3.5.1 PubMed:10373108
-
Cofactor: Evidence: Note:
FAD - Binds 1 FAD covalently per subunit (PubMed:10373108, PubMed:24374335, PubMed:26644464). Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE (PubMed:24374335, PubMed:26644464).
Chain : B, N
UniProt : P0AC47 (FRDB_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = fumarate + a quinol 1.3.5.1 PubMed:11850430
-
a menaquinone + succinate = a menaquinol + fumarate 1.3.5.1 PubMed:10373108
-
Cofactor: Evidence: Note:
[2Fe-2S] cluster ECO:0000269 | PubMed:10373108
Binds 1 [2Fe-2S] cluster.
[3Fe-4S] cluster ECO:0000269 | PubMed:10373108
Binds 1 [3Fe-4S] cluster.
[4Fe-4S] cluster ECO:0000269 | PubMed:10373108
Binds 1 [4Fe-4S] cluster.
Chain : C, O
UniProt : P0A8Q0 (FRDC_ECOLI)
Reaction : -
Chain : D, P
UniProt : P0A8Q3 (FRDD_ECOLI)
Reaction : -