Brand  (β version)

PDB ID: 1KFE

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Ligands
Code Name Style Show Link
NA Sodium ion PoSSuM
PLS [3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-serine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1KFE   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHAN SYNTHASE FROM SALMONELLA TYPHIMURIUM WITH L-Ser Bound To The Beta Site
Release Data : 2003-01-07
Compound :
mol_id molecule chains synonym
1 TRYPTOPHAN SYNTHASE ALPHA CHAIN A TRPA
mutation: T183V
mol_id molecule chains
2 TRYPTOPHAN SYNTHASE BETA CHAIN B
Source :
mol_id organism_scientific expression_system
1 Salmonella typhimurium  (taxid:602) Escherichia coli  (taxid:562)
expression_system_plasmid: PSTB7
mol_id organism_scientific expression_system
2 Salmonella typhimurium  (taxid:99287) Escherichia coli  (taxid:562)
strain: LT2
expression_system_plasmid: PSTB7
Authors : Kulik, V., Weyand, M., Siedel, R., Niks, D., Arac, D., Dunn, M.F., Schlichting, I.
Keywords : helix, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

On the Role of AlphaTHR183 in the Allosteric Regulation and Catalytic Mechanism of Tryptophan Synthase

Kulik, V.,Weyand, M.,Siedel, R.  et al.
(2002)  J.Mol.Biol.  324 : 677 - 690

PubMed: 12460570
DOI: 10.1016/S0022-2836(02)01109-9

Reaction

Chain : A
UniProt : P00929 (TRPA_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan 4.2.1.20 HAMAP-Rule:MF_00131
-
Chain : B
UniProt : P0A2K1 (TRPB_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan 4.2.1.20 -
-