Brand  (β version)

PDB ID: 1KEK

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CO2 Carbon dioxide PoSSuM
HTL 2-acetyl-thiamine diphosphate PoSSuM
MG Magnesium ion PoSSuM
SF4 Iron/sulfur cluster PoSSuM
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Structure summary

Code : 1KEK   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of the Free Radical Intermediate of Pyruvate:Ferredoxin Oxidoreductase
Release Data : 2001-12-21
Compound :
mol_id molecule chains
1 Pyruvate-Ferredoxin Oxidoreductase A,B
ec: 1.2.7.1
Source :
mol_id organism_scientific
1 Desulfovibrio africanus  (taxid:873)
Authors : Chabriere, E., Vernede, X., Guigliarelli, B., Charon, M.-H., Hatchikian, E.C., Fontecilla-Camps, J.C.
Keywords : homodimer, 7 domains, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase.

Chabriere, E.,Vernede, X.,Guigliarelli, B.  et al.
(2001)  Science  294 : 2559 - 2563

PubMed: 11752578
DOI: 10.1126/science.1066198

Reaction

Chain : A, B
UniProt : P94692 (PFOR_DESAF)
Reaction: EC: Evidence:
Physiological Direction:
2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate + CoA = 2 reduced [2Fe-2S]-[ferredoxin] + acetyl-CoA + CO2 + H(+) 1.2.7.1 PubMed:7612653
-
Cofactor: Evidence: Note:
[4Fe-4S] cluster ECO:0000269 | PubMed:10048931
ECO:0000269 | PubMed:11752578
ECO:0000269 | PubMed:16472741
ECO:0000269 | PubMed:7612653
Binds 3 [4Fe-4S] clusters per subunit.
thiamine diphosphate ECO:0000269 | PubMed:10048931
ECO:0000269 | PubMed:11752578
ECO:0000269 | PubMed:16472741
Binds 1 thiamine pyrophosphate per subunit.
Mg(2+) ECO:0000269 | PubMed:10048931
ECO:0000269 | PubMed:11752578
ECO:0000269 | PubMed:16472741
Binds 1 Mg(2+) ion per subunit.