Brand  (β version)

PDB ID: 1K9S

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Ligands
Code Name Style Show Link
FM1 2-hydroxymethyl-5-(7-methylamino-3h-pyrazolo[4,3-D]pyrimidin-3-yl)-tetrahydro-furan-3,4-diol PoSSuM
FM2 2-(7-amino-6-methyl-3h-pyrazolo[4,3-D]pyrimidin-3-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1K9S   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : PURINE NUCLEOSIDE PHOSPHORYLASE FROM E. COLI IN COMPLEX WITH FORMYCIN A DERIVATIVE AND PHOSPHATE
Release Data : 2001-11-28
Compound :
mol_id molecule chains
1 PURINE NUCLEOSIDE PHOSPHORYLASE A,B,C,D,E,F
ec: 2.4.2.1
Source :
mol_id organism_scientific
1 Escherichia coli  (taxid:562)
Authors : Koellner, G., Bzowska, A., Wielgus-Kutrowska, B., Luic, M., Steiner, T., Saenger, W., Stepinski, J.
Keywords : GLYCOSYLTRANSFERASE, PURINE NUCLEOSIDE PHOSPHORYLASE, TRANSFERASE, E. COLI
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Open and closed conformation of the E. coli purine nucleoside phosphorylase active center and implications for the catalytic mechanism.

Koellner, G.,Bzowska, A.,Wielgus-Kutrowska, B.  et al.
(2002)  J.Mol.Biol.  315 : 351 - 371

PubMed: 11786017
DOI: 10.1006/jmbi.2001.5211

Reaction

Chain : A, B, C, D, E, F
UniProt : P0ABP8 (DEOD_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate 2.4.2.1 HAMAP-Rule:MF_01627
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a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy- alpha-D-ribose 1-phosphate + a purine nucleobase 2.4.2.1 HAMAP-Rule:MF_01627
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inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine 2.4.2.1 PubMed:21672603, PubMed:235429, PubMed:11786017
right-to-left PubMed:235429
adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate 2.4.2.1 PubMed:21672603, PubMed:235429, PubMed:30337572
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guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine 2.4.2.1 PubMed:21672603, PubMed:235429
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2'-deoxyadenosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + adenine 2.4.2.1 PubMed:235429
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2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + guanine 2.4.2.1 PubMed:235429
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2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + hypoxanthine 2.4.2.1 PubMed:235429
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