Brand  (β version)

PDB ID: 1K83

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Ligands
Code Name Style Show Link
MN Manganese (II) ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
CSX S-oxy cysteine
HYP 4-hydroxyproline
ILX 4,5-dihydroxyisoleucine
TRX 6-hydroxytryptophan
Glycosylation
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Modification
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Structure summary

Code : 1K83   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION/TOXIN
Title : Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin
Release Data : 2002-02-13
Compound :
mol_id molecule chains synonym
1 DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT A RPB1
ec: 2.7.7.6
mol_id molecule chains synonym
2 DNA-DIRECTED RNA POLYMERASE II 140KD POLYPEPTIDE B RPB2
ec: 2.7.7.6
mol_id molecule chains synonym
3 DNA-DIRECTED RNA POLYMERASE II 45KD POLYPEPTIDE C RPB3
ec: 2.7.7.6
mol_id molecule chains synonym
4 DNA-DIRECTED RNA POLYMERASE II 27KD POLYPEPTIDE E RPB5
ec: 2.7.7.6
mol_id molecule chains synonym
5 DNA-DIRECTED RNA POLYMERASE II 23KD POLYPEPTIDE F RPB6
ec: 2.7.7.6
mol_id molecule chains synonym
6 DNA-DIRECTED RNA POLYMERASE II 14.5KD POLYPEPTIDE H RPB8
ec: 2.7.7.6
mol_id molecule chains synonym
7 DNA-DIRECTED RNA POLYMERASE II 14.2KD POLYPEPTIDE I RPB9
ec: 2.7.7.6
mol_id molecule chains synonym
8 DNA-DIRECTED RNA POLYMERASE II 8.3KD POLYPEPTIDE J RPB10
ec: 2.7.7.6
mol_id molecule chains synonym
9 DNA-DIRECTED RNA POLYMERASE II 13.6KD POLYPEPTIDE K RPB11
ec: 2.7.7.6
mol_id molecule chains synonym
10 DNA-DIRECTED RNA POLYMERASE II 7.7KD POLYPEPTIDE L RPB12
ec: 2.7.7.6
mol_id molecule chains synonym
11 ALPHA AMANITIN M AMATOXIN
Source :
mol_id organism_scientific organism_common
1 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
strain: DELTA-RPB4
mol_id organism_scientific organism_common
2 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
strain: DELTA-RPB4
mol_id organism_scientific organism_common
3 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
strain: DELTA-RPB4
mol_id organism_scientific organism_common
4 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
strain: DELTA-RPB4
mol_id organism_scientific organism_common
5 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
strain: DELTA-RPB4
mol_id organism_scientific organism_common
6 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
strain: DELTA-RPB4
mol_id organism_scientific organism_common
7 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
strain: DELTA-RPB4
mol_id organism_scientific organism_common
8 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
strain: DELTA-RPB4
mol_id organism_scientific organism_common
9 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
strain: DELTA-RPB4
mol_id organism_scientific organism_common
10 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST
strain: DELTA-RPB4
mol_id organism_scientific
11 AMANITA PHALLOIDES  (taxid:67723)
Authors : Bushnell, D.A., Cramer, P., Kornberg, R.D.
Keywords : TRANSCRIPTION-TOXIN COMPLEX, ALPHA AMANITIN, TOXIN, INHIBITOR, POLYMERASE, TRANSFERASE, DNA BINDING, ZINC-FINGER, PHOSPHOPROTEIN, TRANSCRIPTION, UBL TRANSCRIPTION-TOXIN COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Structural Basis of Transcription: Alpha-Amanitin-RNA Polymerase II Cocrystal at 2.8 A Resolution.

Bushnell, D.A.,Cramer, P.,Kornberg, R.D.
(2002)  Proc.Natl.Acad.Sci.USA  99 : 1218

PubMed: 11805306
DOI: 10.1073/PNAS.251664698

Reaction

Chain : A
UniProt : P04050 (RPB1_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.6 -
-
Chain : B
UniProt : P08518 (RPB2_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.6 -
-
Chain : C
UniProt : P16370 (RPB3_YEAST)
Reaction : -
Chain : E
UniProt : P20434 (RPAB1_YEAST)
Reaction : -
Chain : F
UniProt : P20435 (RPAB2_YEAST)
Reaction : -
Chain : H
UniProt : P20436 (RPAB3_YEAST)
Reaction : -
Chain : I
UniProt : P27999 (RPB9_YEAST)
Reaction : -
Chain : J
UniProt : P22139 (RPAB5_YEAST)
Reaction : -
Chain : K
UniProt : P38902 (RPB11_YEAST)
Reaction : -
Chain : L
UniProt : P40422 (RPAB4_YEAST)
Reaction : -
Chain : M
UniProt : P85421 (AAMAT_AMAPH)
Reaction : -