Brand  (β version)

PDB ID: 1K7Y

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Ligands
Code Name Style Show Link
B12 Cobalamin PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1K7Y   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : E. coli MetH C-terminal fragment (649-1227)
Release Data : 2001-12-21
Compound :
mol_id molecule chains
1 methionine synthase A
ec: 2.1.1.13
fragment: c-terminal activation complex, residues 651-1227
mutation: H759G
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: Escherichia coli
expression_system_strain: XL1-Blue
expression_system_vector_type: plasmid
expression_system_plasmid: pTrc99A
Authors : Bandarian, V., Pattridge, K.A., Lennon, B.W., Huddler, D.P., Matthews, R.G., Ludwig, M.L.
Keywords : MOTION OF 4-HELIX BUNDLE, DOMAIN INTERACTIONS, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 3.0 Å )
Citation :

Domain alternation switches B(12)-dependent methionine synthase to the activation conformation.

Bandarian, V.,Pattridge, K.A.,Lennon, B.W.  et al.
(2002)  Nat.Struct.Biol.  9 : 53 - 56

PubMed: 11731805
DOI: 10.1038/nsb738

Reaction

Chain : A
UniProt : P13009 (METH_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine 2.1.1.13 PubMed:8652590, PubMed:9201956
-
Cofactor: Evidence: Note:
methylcob(III)alamin ECO:0000269 | PubMed:7992050
-
Zn(2+) ECO:0000269 | PubMed:9398304
Binds 1 zinc ion per subunit.