Brand  (β version)

PDB ID: 1K74

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Ligands
Code Name Style Show Link
544 2-(1-methyl-3-oxo-3-phenyl-propylamino)-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid PoSSuM
9CR (9cis)-retinoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1K74   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides.
Release Data : 2001-12-05
Compound :
mol_id molecule chains synonym
1 Retinoic acid receptor RXR-alpha A RXRalpha
fragment: ligand binding domain - residues 225 - 462
mol_id molecule chains synonym
2 Peroxisome proliferator activated receptor gamma D PPARgamma
fragment: ligand binding domain residues - 206 - 477
mol_id molecule chains
3 steroid receptor coactivator B,E
fragment: src-1 peptide
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_vector: pACYC184
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_vector: prSET
mol_id organism_scientific
3
synthetic: yes
other_details: Chemically synthesized 25mer portion of the human src-1 coactivator peptide.
Authors : Xu, H.E., Lambert, M.H., Montana, V.G., Moore, L.B., Collins, J.L., Oplinger, J.A., Kliewer, S.A., Gampe Jr., R.T., McKee, D.D., Moore, J.T., Willson, T.M.
Keywords : The heterodimer of the nuclear receptor ligand binding domains of RXRalpha and PPARgamma bound respectively with 9-cis retinoic acid and GW409544 and coactivator peptides, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.

Xu, H.E.,Lambert, M.H.,Montana, V.G.  et al.
(2001)  Proc.Natl.Acad.Sci.USA  98 : 13919 - 13924

PubMed: 11698662
DOI: 10.1073/pnas.241410198

Reaction

Chain : A
UniProt : P19793 (RXRA_HUMAN)
Reaction : -
Chain : D
UniProt : P37231 (PPARG_HUMAN)
Reaction : -
Chain : B, E
UniProt : O43792 (NCOA1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] 2.3.1.48 -
-