Brand  (β version)

PDB ID: 1JWV

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CB4 Pinacol[[2-amino-alpha-(1-carboxy-1-methylethoxyimino)-4-thiazoleacetyl]amino]methaneboronate PoSSuM
K Potassium ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1JWV   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of G238A mutant of TEM-1 beta-lactamase in complex with a boronic acid inhibitor (sefb4)
Release Data : 2002-06-05
Compound :
mol_id molecule chains
1 BETA-LACTAMASE TEM A
ec: 3.5.2.6
fragment: TEM-1
mutation: G238A
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: bla
expression_system_strain: SF120
expression_system_vector_type: Plasmid
expression_system_plasmid: pAiter EX II
Authors : Wang, X., Minasov, G., Shoichet, B.K.
Keywords : TEM-1, beta-lactamase, serine hydrolase, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs.

Wang, X.,Minasov, G.,Shoichet, B.K.
(2002)  J.Mol.Biol.  320 : 85 - 95

PubMed: 12079336
DOI: 10.1016/S0022-2836(02)00400-X

Reaction

Chain : A
UniProt : P62593 (BLAT_ECOLX)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE- ProRule:PRU10101
-