Brand  (β version)

PDB ID: 1JRB

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Ligands
Code Name Style Show Link
FMN Flavin mononucleotide PoSSuM
ORO Orotic acid PoSSuM
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Structure summary

Code : 1JRB   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : The P56A mutant of Lactococcus lactis dihydroorotate dehydrogenase A
Release Data : 2003-09-09
Compound :
mol_id molecule chains
1 dihydroorotate dehydrogenase A A,B
ec: 1.3.3.1
mutation: P56A
Source :
mol_id organism_scientific expression_system
1 Lactococcus lactis  (taxid:1358) Escherichia coli  (taxid:562)
expression_system_strain: SO6645
expression_system_vector_type: plasmid
expression_system_plasmid: pUHE23
Authors : Norager, S., Arent, S., Bjornberg, O., Ottosen, M., Lo Leggio, L., Jensen, K.F., Larsen, S.
Keywords : Homodimer, alpha-beta barrel, flavoprotein, orotate complex, mutant enzyme, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function

Norager, S.,Arent, S.,Bjornberg, O.  et al.
(2003)  J.Biol.Chem.  278 : 28812 - 28822

PubMed: 12732650
DOI: 10.1074/jbc.M303767200

Active site of dihydroorotate dehydrogenase A from Lactococcus lactis investigated by chemical modification and mutagenesis

Bjornberg, O.,Rowland, P.,Larsen, S.  et al.
(1997)  Biochemistry  36 : 16197 - 16205

DOI: 10.1021/bi971628y

The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function

Rowland, P.,Bjornberg, O.,Nielsen, F.S.  et al.
(1998)  Protein Sci.  7 : 1269 - 1279

The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis

Rowland, P.,Nielsen, F.S.,Jensen, K.F.  et al.
(1997)  Structure  5 : 239 - 252

DOI: 10.1016/S0969-2126(97)00182-2

Purification and characterisation of dihydroorotate dehydrogenase A from Lactococcus lactis, crystallisation and preliminary X-ray diffraction studies of the enzyme

Nielsen, F.S.,Rowland, P.,Larsen, S.  et al.
(1996)  Protein Sci.  5 : 852 - 856

Reaction

Chain : A, B
UniProt : P54321
Reaction : -