Brand  (β version)

PDB ID: 1JIZ

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
CA Calcium ion PoSSuM
CGS N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride PoSSuM
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Structure summary

Code : 1JIZ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure Analysis of human Macrophage Elastase MMP-12
Release Data : 2002-07-03
Compound :
mol_id molecule chains synonym
1 macrophage elastase MMP-12 A,B MACROPHAGE METALLOELASTASE
ec: 3.4.24.65
fragment: catalytic domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Nar, H., Werle, K., Bauer, M.M.T., Dollinger, H., Jung, B.
Keywords : matrix metalloproteinase, MMP-12, chronic obstructive pulmonary disease, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor.

Nar, H.,Werle, K.,Bauer, M.M.  et al.
(2001)  J.Mol.Biol.  312 : 743 - 751

PubMed: 11575929
DOI: 10.1006/jmbi.2001.4953

Reaction

Chain : A, B
UniProt : P39900 (MMP12_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin. 3.4.24.65 -
-
Cofactor: Evidence: Note:
Ca(2+) - Binds 4 Ca(2+) ions per subunit.
Zn(2+) - Binds 2 Zn(2+) ions per subunit.