Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
01S N-[(2r)-2-(hydroxycarbamoyl)-4-methylpentanoyl]-L-alanylglycinamide
CA Calcium ion
ZN Zinc ion
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 1JAQ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : COMPLEX OF 1-HYDROXYLAMINE-2-ISOBUTYLMALONYL-ALA-GLY-NH2 WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM)
Release Data : 1996-07-11
Compound :
mol_id molecule chains synonym
1 MATRIX METALLO PROTEINASE-8 (MET80 FORM) A MMP-8-MET80 FORM
ec: 3.4.24.34
fragment: CATALYTIC DOMAIN, RESIDUES 80 - 242
other_details: MMP-8 IS IDENTICAL TO THE HUMAN NEUTROPHIL COLLAGENASE
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
cell: NEUTROPHILS
Authors : Grams, F., Reinemer, P., Powers, J.C., Kleine, T., Piper, M., Tschesche, H., Huber, R., Bode, W.
Keywords : METALLOPROTEASE, ZINC-ENDOPEPTIDASE, METZINCINS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.

Grams, F.,Reinemer, P.,Powers, J.C.  et al.
(1995)  Eur.J.Biochem.  228 : 830 - 841

PubMed: 7737183
DOI: 10.1111/j.1432-1033.1995.tb20329.x

The X-Ray Crystal Structure of the Catalytic Domain of Human Neutrophil Collagenase Inhibited by a Substrate Analogue Reveals the Essentials for Catalysis and Specificity

Bode, W.,Reinemer, P.,Huber, R.  et al.
(1994)  Embo J.  13 : 1263

Structural Implications for the Role of the N Terminus in the 'Superactivation' of Collagenases. A Crystallographic Study

Reinemer, P.,Grams, F.,Huber, R.  et al.
(1994)  FEBS Lett.  338 : 227

Chain : A
UniProt : P22894 (MMP8_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I. 3.4.24.34 -
-