Brand  (β version)

PDB ID: 1IYO

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Ligands
Code Name Style Show Link
CEF Cefotaxime, c3' cleaved, open, bound form PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1IYO   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Toho-1 beta-Lactamase In Complex With Cefotaxime
Release Data : 2002-12-11
Compound :
mol_id molecule chains
1 Toho-1 beta-lactamase A
ec: 3.5.2.6
mutation: E166A
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_vector_type: PLASMID
expression_system_plasmid: pUC119
Authors : Shimamura, T., Ibuka, A., Fushinobu, S., Wakagi, T., Ishiguro, M., Ishii, Y., Matsuzawa, H.
Keywords : extended-spectrum, ESBL, BETA-LACTAMASE, ACYL-ENZYME, cefotaxime, complex, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.8 Å )
Citation :

Acyl-intermediate Structures of the Extended-spectrum Class A beta -Lactamase, Toho-1, in Complex with Cefotaxime, Cephalothin, and Benzylpenicillin.

Shimamura, T.,Ibuka, A.,Fushinobu, S.  et al.
(2002)  J.Biol.Chem.  277 : 46601 - 46608

PubMed: 12221102
DOI: 10.1074/jbc.M207884200

Reaction

Chain : A
UniProt : Q47066 (BLT1_ECOLX)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE- ProRule:PRU10101
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