Brand  (β version)

PDB ID: 1IY7

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Ligands
Code Name Style Show Link
CXA Phenylalanine-N-sulfonamide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1IY7   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of CPA and sulfamide-based inhibitor complex
Release Data : 2003-01-28
Compound :
mol_id molecule chains
1 Carboxypeptidase A A
ec: 3.4.17.1
Source :
mol_id organism_scientific organism_common expression_system
1 Bos taurus  (taxid:9913) Cattle Escherichia coli  (taxid:562)
Authors : Kim, S.J., Woo, J.R., Park, J.D., Kim, D.H., Ryu, S.E.
Keywords : Protein-Inhibitor complex, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Sulfamide-Based Inhibitors for Carboxypeptidase A. Novel Type Transition State Analogue Inhibitors for Zinc Proteases

Park, J.D.,Kim, D.H.,Kim, S.J.  et al.
(2002)  J.Med.Chem.  45 : 5295 - 5302

PubMed: 12431056
DOI: 10.1021/jm020258v

Reaction

Chain : A
UniProt : P00730 (CBPA1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. 3.4.17.1 UniProtKB:P15085
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H2O + leukotriene C4 = glycine + leukotriene F4 - PubMed:12729612
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