Brand  (β version)

PDB ID: 1IVH

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Ligands
Code Name Style Show Link
COS Coenzyme a persulfide PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1IVH   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : STRUCTURE OF HUMAN ISOVALERYL-COA DEHYDROGENASE AT 2.6 ANGSTROMS RESOLUTION: STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITY
Release Data : 1998-05-20
Compound :
mol_id molecule chains
1 ISOVALERYL-COA DEHYDROGENASE A,B,C,D
ec: 1.3.99.10
other_details: EACH SUBUNIT CONTAINS ONE NON-COVALENTLY BOUND FAD MOLECULE AND ONE NON-COVALENTLY BOUND COA PER SULFIDE MOLECULE
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
organ: LIVER
organelle: MITOCHONDRIA
gene: IVD
expression_system_strain: JM105
expression_system_cellular_location: CYTOPLASM
expression_system_vector_type: PLASMID
expression_system_vector: PKK233-3
expression_system_plasmid: PKMHIVD
other_details: THE CDNA WAS ALTERED TO ACCOMMODATE ESCHERICHIA COLI CODON USAGE IN ORDER TO ACHIEVE A HIGH LEVEL OF EXPRESSION. THE MOLECULE WAS THEN CLONED, EXPRESSED, AND PURIFIED AS DESCRIBED IN\: MOHSEN, A.W. AND VOCKLEY, J. (1995) BIOCHEMISTRY, 34\:10146-10152
Authors : Tiffany, K.A., Roberts, D.L., Wang, M., Paschke, R., Mohsen, A.-W.A., Vockley, J., Kim, J.J.P.
Keywords : OXIDOREDUCTASE, ACYL-COA DEHYDROGENASE, FLAVOPROTEIN, ISOVALERYL-COA, ISOVALERIC ACIDEMIA
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity,.

Tiffany, K.A.,Roberts, D.L.,Wang, M.  et al.
(1997)  Biochemistry  36 : 8455 - 8464

PubMed: 9214289
DOI: 10.1021/bi970422u

Reaction

Chain : A, B, C, D
UniProt : P26440 (IVD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron- transfer flavoprotein] 1.3.8.4 PubMed:7640268
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H(+) + oxidized [electron-transfer flavoprotein] + pentanoyl- CoA = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein] - PubMed:7640268
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H(+) + hexanoyl-CoA + oxidized [electron-transfer flavoprotein] = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein] - PubMed:7640268
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butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] 1.3.8.1 PubMed:7640268
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