Brand  (β version)

PDB ID: 1IV4

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
C5P Cytidine-5'-monophosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1IV4   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase (bound form Substrate)
Release Data : 2002-09-11
Compound :
mol_id molecule chains
1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase A,B,C,D,E,F
ec: 4.6.1.12
mutation: L41M, L81M, L120M
Source :
mol_id organism_scientific expression_system
1 Thermus thermophilus  (taxid:274) Escherichia coli  (taxid:562)
expression_system_vector_type: plasmid
expression_system_plasmid: PET11B
Authors : Kishida, H., Wada, T., Unzai, S., Kuzuyama, T., Terada, T., Sirouzu, M., Yokoyama, S., Tame, J.R.H., Park, S.-Y., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Keywords : isoprenoid, non-mevalonate, synthase, RIKEN Structural Genomics/Proteomics Initiative, RSGI, Structural Genomics, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.55 Å )
Citation :

Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.

Kishida, H.,Wada, T.,Unzai, S.  et al.
(2003)  Acta Crystallogr.,Sect.D  59 : 23 - 31

PubMed: 12499535
DOI: 10.1107/S0907444902017705

Reaction

Chain : A, B, C, D, E, F
UniProt : Q8RQP5 (ISPF_THET8)
Reaction: EC: Evidence:
Physiological Direction:
4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D- erythritol 2,4-cyclic diphosphate + CMP 4.6.1.12 HAMAP-Rule:MF_00107, PubMed:12499535
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