Brand  (β version)

PDB ID: 1IO4

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Structure summary

Code : 1IO4   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION/DNA
Title : CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN-CBFBETA CORE DOMAIN HETERODIMER AND C/EBPBETA BZIP HOMODIMER BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER
Release Data : 2001-03-12
Compound :
mol_id molecule chains
1 CSF-1R PROMOTER E
mol_id molecule chains
2 CSF-1R PROMOTER F
mol_id molecule chains synonym
3 CAAT/ENHANCER BINDING PROTEIN BETA A,B C/EBP BETA
fragment: BZIP DOMAIN
mol_id molecule chains synonym
4 RUNT-RELATED TRANSCRIPTION FACTOR 1 C CORE-BINDING FACTOR, ALPHA B SUBUNIT, PEPB2-ALPHA B
fragment: RUNT DOMAIN
mol_id molecule chains synonym
5 CORE-BINDING FACTOR, BETA SUBUNIT D PEBP2-BETA, CBF-BETA
fragment: CORE DOMAIN
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector: PLASMID
expression_system_plasmid: PAR2156
mol_id organism_scientific organism_common expression_system
4 Mus musculus  (taxid:10090) House mouse Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector: PLASMID
expression_system_plasmid: PAR2156
mol_id organism_scientific organism_common expression_system
5 Mus musculus  (taxid:10090) House mouse Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector: PLASMID
expression_system_plasmid: PAR2156
Authors : Tahirov, T.H., Ogata, K.
Keywords : PROTEIN-DNA COMPLEX, TRANSCRIPTION FACTOR, BZIP, RUNX, RUNT, C/EBP, CBF, CORE BINDING FACTOR, AML1, AML, TRANSCRIPTION-DNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.

Tahirov, T.H.,Inoue-Bungo, T.,Morii, H.  et al.
(2001)  Cell(Cambridge,Mass.)  104 : 755 - 767

PubMed: 11257229
DOI: 10.1016/S0092-8674(01)00271-9

Crystallization and Preliminary X-Ray Analyses of Quaternary, Ternary and Binary Protein-DNA Complexes with Involvement of AML1/Runx-1/Cbfalpha Runt Domain, Cbfbeta and the C/EBPbeta bZIP Region

Tahirov, T.H.,Inoue, T.,Sasaki, M.  et al.
To Be Published 

Reaction

Chain : A, B
UniProt : P17676 (CEBPB_HUMAN)
Reaction : -
Chain : C
UniProt : Q03347
Reaction : -
Chain : D
UniProt : Q08024 (PEBB_MOUSE)
Reaction : -