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Ligands
Code Name Style Show Link
9DG 9-deazaguanine
Non-standard Residues
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Glycosylation
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Modification
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Code : 1IL4   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : STRUCTURE OF RICIN A CHAIN BOUND WITH INHIBITOR 9-DEAZAGUANINE
Release Data : 2002-01-16
Compound :
mol_id molecule chains
1 RICIN A CHAIN A
ec: 3.2.2.22
Source :
mol_id organism_scientific organism_common expression_system
1 Ricinus communis  (taxid:3988) Castor bean Escherichia coli  (taxid:562)
Authors : Miller, D.J., Ravikumar, K., Shen, H., Suh, J.-K., Kerwin, S.M., Robertus, J.D.
Keywords : STRUCTURE-BASED DESIGN, TOXIN-INHIBITOR COMPLEX, GLYCOSIDASE, HYDROLASE, RIBOSOME-INHIBITING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.6 Å )
Citation :

Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.

Miller, D.J.,Ravikumar, K.,Shen, H.  et al.
(2002)  J.Med.Chem.  45 : 90 - 98

PubMed: 11754581
DOI: 10.1021/jm010186s

Chain : A
UniProt : P02879 (RICI_RICCO)
Reaction: EC: Evidence:
Physiological Direction:
[Ricin A chain]
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
3.2.2.22 -
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