Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
CC0 (4-{2-acetylamino-2-[1-(3-carbamoyl-4-cyclohexylmethoxy-phenyl)-ethylcarbamoyl}-ethyl}-2-phosphono-phenoxy)-acetic acid
Code : 1IJR
Header : TRANSFERASE/SIGNALING PROTEIN
Title : Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic
Release Data : 2002-05-01
Compound :
mol_id molecule chains
1 PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK A
ec: 2.7.1.112
fragment: SH2 DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Kawahata, N.H., Yang, M.H., Luke, G.P., Shakespeare, W.C., Sundaramoorthi, R.
Keywords : Tyrosine-protein kinase, TRANSFERASE-SIGNALING PROTEIN COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain.

Kawahata, N.,Yang, M.G.,Luke, G.P.  et al.
(2001)  Bioorg.Med.Chem.Lett.  11 : 2319 - 2323

PubMed: 11527723
DOI: 10.1016/S0960-894X(01)00446-2

Chain : A
UniProt : P06239 (LCK_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.