Brand  (β version)

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
DPN D-phenylalanine
OPR (5s)-5-amino-8-carbamimidamido-4-oxooctanoic acid
Glycosylation
Code Name Emphasize
Modification
Code Name Show
ACE Acetyl group
Code : 1IHS   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN ALPHA-THROMBIN AND NON-HYDROLYZABLE BIFUNCTIONAL INHIBITORS, HIRUTONIN-2 AND HIRUTONIN-6
Release Data : 1994-01-31
Compound :
mol_id molecule chains
1 ALPHA-THROMBIN (SMALL SUBUNIT) L
ec: 3.4.21.5
mol_id molecule chains
2 ALPHA-THROMBIN (LARGE SUBUNIT) H
ec: 3.4.21.5
mol_id molecule chains
3 HIRUTONIN I
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific
3
Authors : Zdanov, A., Cygler, M.
Keywords : HYDROLASE(SERINE PROTEINASE), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.

Zdanov, A.,Wu, S.,DiMaio, J.  et al.
(1993)  Proteins  17 : 252 - 265

PubMed: 8272424
DOI: 10.1002/prot.340170304

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : I
UniProt : P28504 (HIR2_HIRME)
Reaction : -