Brand  (β version)

PDB ID: 1IEL

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Ligands
Code Name Style Show Link
PO4 Phosphate ion PoSSuM
CAZ Acylated ceftazidime PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1IEL   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of AmpC beta-lactamase from E. coli in Complex with Ceftazidime
Release Data : 2001-08-15
Compound :
mol_id molecule chains synonym
1 beta-lactamase A,B AmpC beta-lactamase, cephalosporinase
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_strain: JM109
expression_system_vector_type: plasmid
expression_system_plasmid: p0G0295
Authors : Powers, R.A., Caselli, E., Focia, P.J., Prati, F., Shoichet, B.K.
Keywords : cephalosporinase, beta-lactamase, serine hydrolase, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design.

Powers, R.A.,Caselli, E.,Focia, P.J.  et al.
(2001)  Biochemistry  40 : 9207 - 9214

PubMed: 11478888
DOI: 10.1021/bi0109358

Reaction

Chain : A, B
UniProt : P00811 (AMPC_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE- ProRule:PRU10102
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