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Ligands
Code Name Style Show Link
COT Coa-S-acetyl tryptamine
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Code : 1IB1   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN/TRANSFERASE
Title : CRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX
Release Data : 2001-05-02
Compound :
mol_id molecule chains synonym
1 14-3-3 ZETA ISOFORM A,B,C,D PROTEIN KINASE C INHIBITOR PROTEIN-1
mol_id molecule chains synonym
2 SEROTONIN N-ACETYLTRANSFERASE E,F,G,H ARALKYLAMINE N-ACETYLTRANSFERASE, AA-NAT, SEROTONIN ACETYLASE
ec: 2.3.1.87
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: YWHAZ
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET14B
mol_id organism_scientific organism_common expression_system
2 Ovis aries  (taxid:9940) Sheep Escherichia coli  (taxid:562)
gene: AANAT OR SNAT
expression_system_strain: BL21(DE3)PLYS
expression_system_vector_type: PLASMID
expression_system_plasmid: PGEX-4T-1
Authors : Obsil, T., Ghirlando, R., Klein, D.C., Ganguly, S., Dyda, F.
Keywords : N-ACETYL TRANSFERASE, 14-3-3, SIGNAL TRANSDUCTION, PROTEIN-PROTEIN COMPLEX, PHOSPHORYLATION, SIGNALING PROTEIN-TRANSFERASE COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.7 Å )
Citation :

Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.

Obsil, T.,Ghirlando, R.,Klein, D.C.  et al.
(2001)  Cell(Cambridge,Mass.)  105 : 257 - 267

PubMed: 11336675
DOI: 10.1016/S0092-8674(01)00316-6

Chain : A, B, C, D
UniProt : P63104 (1433Z_HUMAN)
Reaction : -
Chain : E, F, G, H
UniProt : Q29495 (SNAT_SHEEP)
Reaction: EC: Evidence:
Physiological Direction:
a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+) 2.3.1.87 PubMed:10319816, PubMed:11884405, PubMed:11902838, PubMed:18362150
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