Brand  (β version)

PDB ID: 1I7Q

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Ligands
Code Name Style Show Link
BEZ Benzoic acid PoSSuM
GLU Glutamic acid PoSSuM
MG Magnesium ion PoSSuM
PYR Pyruvic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 1I7Q   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : ANTHRANILATE SYNTHASE FROM S. MARCESCENS
Release Data : 2001-05-16
Compound :
mol_id molecule chains synonym
1 ANTHRANILATE SYNTHASE A,C Anthranilate Synthase TrpE
ec: 4.1.3.27
mol_id molecule chains synonym
2 TRPG B,D Anthranilate Synthase TrpG
ec: 4.1.3.27
Source :
mol_id organism_scientific expression_system
1 Serratia marcescens  (taxid:615) Escherichia coli  (taxid:562)
mol_id organism_scientific expression_system
2 Serratia marcescens  (taxid:615) Escherichia coli  (taxid:562)
Authors : Spraggon, G., Kim, C., Nguyen-Huu, X., Yee, M.-C., Yanofsky, C., Mills, S.E.
Keywords : ANTHRANILATE SYNTHASE, GLUTAMYL THIOESTER, ANTHRANILATE BIOSYNTHESIS, CHORISMATE BINDING, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan.

Spraggon, G.,Kim, C.,Nguyen-Huu, X.  et al.
(2001)  Proc.Natl.Acad.Sci.USA  98 : 6021 - 6026

PubMed: 11371633
DOI: 10.1073/pnas.111150298

Reaction

Chain : A, C
UniProt : P00897 (TRPE_SERMA)
Reaction: EC: Evidence:
Physiological Direction:
chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate 4.1.3.27 -
-
Chain : B, D
UniProt : P00900 (TRPG_SERMA)
Reaction: EC: Evidence:
Physiological Direction:
chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate 4.1.3.27 -
-