Brand  (β version)

PDB ID: 1I48

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Ligands
Code Name Style Show Link
PLP Pyridoxal-5'-phosphate PoSSuM
CCO Carboxymethylthio-3-(3-chlorophenyl)-1,2,4-oxadiazol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1I48   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : CYSTATHIONINE GAMMA-SYNTHASE IN COMPLEX WITH THE INHIBITOR CTCPO
Release Data : 2001-09-05
Compound :
mol_id molecule chains
1 CYSTATHIONINE GAMMA-SYNTHASE A,B,C,D,E,F,G,H,I,J,K,L
ec: 4.2.99.9
Source :
mol_id organism_scientific organism_common expression_system
1 Nicotiana tabacum  (taxid:4097) Common tobacco Escherichia coli BL21(DE3)  (taxid:469008)
gene: METB
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PENCN1117
Authors : Steegborn, C., Laber, B., Messerschmidt, A., Huber, R., Clausen, T.
Keywords : PLP-dependent enzyme, homotetramer, inhibitor complex, CTCPO, LYASE
Exp. method : X-RAY DIFFRACTION ( 3.25 Å )
Citation :

Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor.

Steegborn, C.,Laber, B.,Messerschmidt, A.  et al.
(2001)  J.Mol.Biol.  311 : 789 - 801

PubMed: 11518531
DOI: 10.1006/jmbi.2001.4880

Reaction

Chain : A, B, C, D, E, F, G, H, I, J, K, L
UniProt : Q9ZPL5 (CGS1_TOBAC)
Reaction: EC: Evidence:
Physiological Direction:
O-phospho-L-homoserine + L-cysteine = L,L-cystathionine + phosphate 2.5.1.160 PubMed:10595588
-
O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+) - PubMed:10595588
-
Cofactor: Evidence: Note:
pyridoxal 5'-phosphate ECO:0000269 | PubMed:10438597
ECO:0000269 | PubMed:11518531
Binds 1 pyridoxal 5'-phosphate per subunit.