Brand  (β version)

PDB ID: 1HYV

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
SO4 Sulfate ion PoSSuM
TTA Tetraphenyl-arsonium PoSSuM
Non-standard Residues
Code Name Show
CAF S-dimethylarsinoyl-cysteine
Glycosylation
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Structure summary

Code : 1HYV   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : HIV INTEGRASE CORE DOMAIN COMPLEXED WITH TETRAPHENYL ARSONIUM
Release Data : 2001-04-04
Compound :
mol_id molecule chains
1 INTEGRASE A
ec: 2.7.7.49
fragment: CATALYTIC CORE DOMAIN (RESIDUES 50-212)
mutation: F185K
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus 1  (taxid:11676) Escherichia coli  (taxid:562)
Authors : Molteni, V., Greenwald, J., Rhodes, D., Hwang, Y., Kwiatkowski, W., Bushman, F.D., Siegel, J.S., Choe, S.
Keywords : DNA INTEGRATION, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.7 Å )
Citation :

Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain.

Molteni, V.,Greenwald, J.,Rhodes, D.  et al.
(2001)  Acta Crystallogr.,Sect.D  57 : 536 - 544

PubMed: 11264582
DOI: 10.1107/S0907444901001652

Reaction

Chain : A
UniProt : Q76353 (Q76353_HV1)
Reaction: EC: Evidence:
Physiological Direction:
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 ARBA:ARBA00000379
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Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 ARBA:ARBA00023415
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000256 | ARBA:ARBA00001946
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