Brand  (β version)

PDB ID: 1HXW

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Ligands
Code Name Style Show Link
RIT Ritonavir PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1HXW   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : HIV-1 PROTEASE DIMER COMPLEXED WITH A-84538
Release Data : 1998-02-04
Compound :
mol_id molecule chains
1 HIV-1 PROTEASE A,B
ec: 3.4.23.16
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus 1  (taxid:11676) Escherichia coli  (taxid:562)
expression_system_strain: SCS-1
expression_system_plasmid: PBS7-CI
Authors : Park, C.H., Nienaber, V., Kong, X.P.
Keywords : ASPARTYL PROTEASE, HYDROLASE, ASPARTIC PROTEINASE, HIV, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.8 Å )
Citation :

ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

Kempf, D.J.,Marsh, K.C.,Denissen, J.F.  et al.
(1995)  Proc.Natl.Acad.Sci.USA  92 : 2484 - 2488

PubMed: 7708670
DOI: 10.1073/pnas.92.7.2484

Reaction

Chain : A, B
UniProt : P12499 (POL_HV1Z2)
Reaction: EC: Evidence:
Physiological Direction:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. 3.4.23.16 PROSITE-ProRule:PRU00275
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Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 ECO:0000250
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3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 ECO:0000250
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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