Brand  (β version)

PDB ID: 1HXE

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Ligands
Code Name Style Show Link
RB Rubidium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1HXE   PDBj   RCSB PDB   PDBe
Header : HYDROLASEE/HYDROLASE INHIBITOR
Title : SERINE PROTEASE
Release Data : 1996-11-08
Compound :
mol_id molecule chains synonym
1 THROMBIN L FACTOR IIA
ec: 3.4.21.5
mol_id molecule chains synonym
2 THROMBIN H FACTOR IIA
ec: 3.4.21.5
mol_id molecule chains
3 HIRUDIN VARIANT-1 I
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
organ: BLOOD
tissue: BLOOD
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
organ: BLOOD
tissue: BLOOD
mol_id organism_scientific
3
Authors : Tulinsky, A., Zhang, E.
Keywords : SERINE PROTEASE IN BLOOD COAGULATION, HYDROLASE, SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HYDROLASEE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

The molecular environment of the Na+ binding site of thrombin.

Zhang, E.,Tulinsky, A.
(1997)  Biophys.Chem.  63 : 185 - 200

PubMed: 9108691
DOI: 10.1016/S0301-4622(96)02227-2

The Na+ Binding Site of Thrombin

Di Cera, E.,Guinto, E.R.,Vindigni, A.  et al.
(1995)  J.Biol.Chem.  270 : 22089

Refined Structure of the Hirudin-Thrombin Complex

Rydel, T.J.,Tulinsky, A.,Bode, W.  et al.
(1991)  J.Mol.Biol.  221 : 583

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : I
UniProt : P01050 (HIRV1_HIRME)
Reaction : -