Brand  (β version)

PDB ID: 1HWL

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Ligands
Code Name Style Show Link
ADP Adenosine-5'-diphosphate PoSSuM
FBI 7-[4-(4-fluoro-phenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl] -3,5-dihydroxy-heptanoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1HWL   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH ROSUVASTATIN (FORMALLY KNOWN AS ZD4522)
Release Data : 2001-05-11
Compound :
mol_id molecule chains synonym
1 HMG-COA REDUCTASE A,B,C,D 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE, HYDROXYMETHYLGLUTARYL-COA REDUCTASE
ec: 1.1.1.34
fragment: CATALYTIC PORTION
mutation: M485I
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HMGCR
expression_system_strain: DH5ALPHA
expression_system_vector_type: PLASMID
expression_system_plasmid: PGEX-CS
Authors : Istvan, E.S., Deisenhofer, J.
Keywords : protein-inhibitor complex, oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Structural mechanism for statin inhibition of HMG-CoA reductase.

Istvan, E.S.,Deisenhofer, J.
(2001)  Science  292 : 1160 - 1164

PubMed: 11349148
DOI: 10.1126/science.1059344

Reaction

Chain : A, B, C, D
UniProt : P04035 (HMDH_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3- methylglutaryl-CoA + 2 NADPH + 2 H(+) 1.1.1.34 PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544
right-to-left PubMed:36745799