Brand  (β version)

PDB ID: 1HUT

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Ligands
Code Name Style Show Link
0G7 D-phenylalanyl-N-[(3s)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1HUT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR/DNA
Title : THE STRUCTURE OF ALPHA-THROMBIN INHIBITED BY A 15-MER SINGLE-STRANDED DNA APTAMER
Release Data : 1994-06-22
Compound :
mol_id molecule chains
1 DNA 5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3' D
mol_id molecule chains synonym
2 ALPHA-Thrombin light chain L COAGULATION FACTOR II, THROMBIN
ec: 3.4.21.5
fragment: RESIDUES 328-363
mol_id molecule chains synonym
3 ALPHA-Thrombin heavy chain H COAGULATION FACTOR II, THROMBIN
ec: 3.4.21.5
fragment: RESIDUES 364-622
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
tissue: BLOOD
secretion: PLASMA
mol_id organism_scientific organism_common
3 Homo sapiens  (taxid:9606) Human
tissue: BLOOD
secretion: PLASMA
Authors : Padmanabhan, K., Padmanabhan, K.P., Ferrara, J.D., Sadler, J.E., Tulinsky, A.
Keywords : THROMBIN, BLOOD CLOTTING, HYDROLASE-HYDROLASE INHIBITOR-DNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.9 Å )
Citation :

The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.

Padmanabhan, K.,Padmanabhan, K.P.,Ferrara, J.D.  et al.
(1993)  J.Biol.Chem.  268 : 17651 - 17654

PubMed: 8102368

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-