Brand  (β version)

PDB ID: 1HT5

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Ligands
Code Name Style Show Link
FL2 Flurbiprofen methyl ester PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
BOG Octyl beta-D-glucopyranoside PoSSuM
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose PoSSuM
Non-standard Residues
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Structure summary

Code : 1HT5   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : THE 2.75 ANGSTROM RESOLUTION MODEL OF OVINE COX-1 COMPLEXED WITH METHYL ESTER FLURBIPROFEN
Release Data : 2001-04-11
Compound :
mol_id molecule chains
1 PROSTAGLANDIN H2 SYNTHASE-1 A,B
ec: 1.14.99.1
Source :
mol_id organism_scientific organism_common
1 Ovis aries  (taxid:9940) Sheep
organ: SEMINAL VESICLE
Authors : Selinsky, B.S., Gupta, K., Sharkey, C.T., Loll, P.J.
Keywords : MEMBRANE PROTEIN, PEROXIDASE, DIOXYGENASE, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.75 Å )
Citation :

Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.

Selinsky, B.S.,Gupta, K.,Sharkey, C.T.  et al.
(2001)  Biochemistry  40 : 5172 - 5180

PubMed: 11318639
DOI: 10.1021/bi010045s

Reaction

Chain : A, B
UniProt : P05979 (PGH1_SHEEP)
Reaction: EC: Evidence:
Physiological Direction:
(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O 1.14.99.1 PubMed:7947975
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(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2 - PubMed:7947975
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prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O - PubMed:7947975
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)- octadecadienoate + A + H2O - PubMed:9448728
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)- octadecadienoate + A + H2O - PubMed:9448728
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)- octadecadienoate + A + H2O - PubMed:9448728
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)- octadecadienoate + A + H2O - PubMed:9448728
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Cofactor: Evidence: Note:
heme b - Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.