Brand  (β version)

PDB ID: 1HS6

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
BES 2-(3-amino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic acid PoSSuM
IMD Imidazole PoSSuM
YB Ytterbium (III) ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1HS6   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN.
Release Data : 2001-06-24
Compound :
mol_id molecule chains
1 LEUKOTRIENE A-4 HYDROLASE A
ec: 3.3.2.6
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_vector_type: PLASMID
expression_system_plasmid: PT3-MB4
Authors : Thunnissen, M.M.G.M., Nordlund, P.N., Haeggstrom, J.Z.
Keywords : protein-inhibitor complex, alpha-beta protein, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.

Thunnissen, M.M.,Nordlund, P.,Haeggstrom, J.Z.
(2001)  Nat.Struct.Biol.  8 : 131 - 135

PubMed: 11175901
DOI: 10.1038/84117

Reaction

Chain : A
UniProt : P09960 (LKHA4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
leukotriene A4 + H2O = leukotriene B4 3.3.2.6 PubMed:11675384, PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:24591641, PubMed:6490615, PubMed:7667299, PubMed:9395533
left-to-right PubMed:11917124
(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate + H2O = resolvin E1 - PubMed:21206090
left-to-right
(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate + H2O = 18S-resolvin E1 - PubMed:21206090
left-to-right
Release of the N-terminal residue from a tripeptide. 3.4.11.4 PubMed:11675384, PubMed:11917124, PubMed:20813919, PubMed:24591641, PubMed:9395533
-
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:11175901
ECO:0000269 | PubMed:12207002
ECO:0000269 | PubMed:15078870
ECO:0000269 | PubMed:18804029
ECO:0000269 | PubMed:24591641
Binds 1 zinc ion per subunit.