Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
YB Ytterbium (III) ion
ZN Zinc ion
ACT Acetate ion
BES 2-(3-amino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic acid
IMD Imidazole
Code : 1HS6
Header : HYDROLASE
Title : STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN.
Release Data : 2001-06-24
Compound :
mol_id molecule chains
1 LEUKOTRIENE A-4 HYDROLASE A
ec: 3.3.2.6
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_vector_type: PLASMID
expression_system_plasmid: PT3-MB4
Authors : Thunnissen, M.M.G.M., Nordlund, P.N., Haeggstrom, J.Z.
Keywords : protein-inhibitor complex, alpha-beta protein, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.

Thunnissen, M.M.,Nordlund, P.,Haeggstrom, J.Z.
(2001)  Nat.Struct.Biol.  8 : 131 - 135

PubMed: 11175901
DOI: 10.1038/84117

Chain : A
UniProt : P09960 (LKHA4_HUMAN)
Reaction : (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa- 7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12- dihydroxyicosa-6,8,10,14-tetraenoate.