Brand  (β version)

PDB ID: 1HOV

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
I52 N-{4-[(1-hydroxycarbamoyl-2-methyl-propyl)-(2-morpholin-4-yl-ethyl)-sulfamoyl]-4-pentyl-benzamide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1HOV   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : SOLUTION STRUCTURE OF A CATALYTIC DOMAIN OF MMP-2 COMPLEXED WITH SC-74020
Release Data : 2001-12-12
Compound :
mol_id molecule chains
1 MATRIX METALLOPROTEINASE-2 A
ec: 3.4.24.24
fragment: CATALYTIC DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_strain: W3110-II5
expression_system_vector_type: RECA
Authors : Feng, Y., Likos, J.J., Zhu, L., Woodward, H., Munie, G., McDonald, J.J., Stevens, A.M., Howard, C.P., De Crescenzo, G.A., Welsch, D., Shieh, H.-S., Stallings, W.C.
Keywords : enzyme-inhibitor complex, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : SOLUTION NMR
Citation :

Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor

Feng, Y.,Likos, J.J.,Zhu, L.  et al.
(2002)  Biochim.Biophys.Acta  1598 : 10 - 23

PubMed: 12147339
DOI: 10.1016/S0167-4838(02)00307-2

1H, 13C and 15N resonance assignments for a truncated and inhibited catalytic domain of matrix metalloproteinase-2


(2000)  J.Biomol.NMR  17 : 85 - 86

Reaction

Chain : A
UniProt : P08253 (MMP2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln. 3.4.24.24 PubMed:11179305, PubMed:11431697, PubMed:12147339, PubMed:2834383
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