Brand  (β version)

color scheme of protein:

chain: Hide other chain(s)

Modified Residues
Code Name Link
0QE Chloromethane
ALV (2s)-2-aminopropane-1,1-diol
MSU Succinic acid monomethyl ester
Code : 1HNE
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-angstroms resolution
Release Data : 1989-10-15
Compound :
mol_id molecule chains
1 HUMAN LEUCOCYTE ELASTASE E
ec: 3.4.21.37
mol_id molecule chains
2 METHOXYSUCCINYL-ALA-ALA-PRO-ALA CHLOROMETHYL KETONE INHIBITOR I
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific
2
synthetic: yes
Authors : Navia, M.A., Mckeever, B.M., Springer, J.P., Lin, T.-Y., Williams, H.R., Fluder, E.M., Dorn, C.P., Hoogsteen, K.
Keywords : HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.84 Å )
Citation :

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.

Navia, M.A.,McKeever, B.M.,Springer, J.P.  et al.
(1989)  Proc.Natl.Acad.Sci.USA  86 : 7 - 11

PubMed: 2911584
DOI: 10.1073/pnas.86.1.7

Crystallization of Human Neutrophil Elastase

Williams, H.R.,Lin, T.-Y.,Navia, M.A.  et al.
(1987)  J.Biol.Chem.  262 : 17178

Chain : E
UniProt : P08246 (ELNE_HUMAN)
Reaction : Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.