Het-PDB Navi2 (PDB: 1HNE)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
ALV	(2s)-2-aminopropane-1,1-diol

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
0QE	Chloromethane
MSU	Succinic acid monomethyl ester

Download interaction data: 1HNE

Code :

1HNE PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-angstroms resolution

Release Data :

1989-10-15

Compound :

mol_id	molecule	chains
1	HUMAN LEUCOCYTE ELASTASE	E
	ec: 3.4.21.37

mol_id	molecule	chains
2	METHOXYSUCCINYL-ALA-ALA-PRO-ALA CHLOROMETHYL KETONE INHIBITOR	I

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific
2
	synthetic: yes

Authors :

Navia, M.A., Mckeever, B.M., Springer, J.P., Lin, T.-Y., Williams, H.R., Fluder, E.M., Dorn, C.P., Hoogsteen, K.

Keywords :

HYDROLASE-HYDROLASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 1.84 Å )

Citation :

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.

Navia, M.A.,McKeever, B.M.,Springer, J.P. et al.
(1989) Proc.Natl.Acad.Sci.USA 86 : 7 - 11

Crystallization of Human Neutrophil Elastase

Williams, H.R.,Lin, T.-Y.,Navia, M.A. et al.
(1987) J.Biol.Chem. 262 : 17178

Chain :

UniProt :

P08246 (ELNE_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Hydrolysis of proteins, including elastin. Preferential cleavage: Val-\|-Xaa > Ala-\|-Xaa.	3.4.21.37	PubMed:36899106
	-	PubMed:36899106

PDB ID: 1HNE