Brand  (β version)

PDB ID: 1HMP

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Ligands
Code Name Style Show Link
5GP Guanosine-5'-monophosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1HMP   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE (GLYCOSYLTRANSFERASE)
Title : THE CRYSTAL STRUCTURE OF HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE WITH BOUND GMP
Release Data : 1995-06-03
Compound :
mol_id molecule chains
1 HYPOXANTHINE GUANINE PHOSPHORIBOSYL-TRANSFERASE A,B
ec: 2.4.2.8
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
Authors : Eads, J.C., Scapin, G., Xu, Y., Grubmeyer, C., Sacchettini, J.C.
Keywords : TRANSFERASE (GLYCOSYLTRANSFERASE)
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP.

Eads, J.C.,Scapin, G.,Xu, Y.  et al.
(1994)  Cell(Cambridge,Mass.)  78 : 325 - 334

PubMed: 8044844
DOI: 10.1016/0092-8674(94)90301-8

Crystal Structure of Orotate Phosphoribosyltransferase

Scapin, G.,Grubmeyer, C.,Sacchettini, J.C.
(1994)  Biochemistry  33 : 1287

Reaction

Chain : A, B
UniProt : P00492 (HPRT_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1- diphosphate 2.4.2.8 PubMed:10338013, PubMed:19527031
right-to-left
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1- diphosphate 2.4.2.8 PubMed:10338013, PubMed:19527031
right-to-left
Cofactor: Evidence: Note:
Mg(2+) - Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.